ea0063gp70 | Thyroid Autoimmune Disorders | ECE2019
Ruggeri Rosaria Maddalena
, Vicchio Teresa Manuela
, Cristani Maria Teresa
, Giovinazzo Salvatore
, Campenni Alfredo
, Cannavo Salvatore
, Trimarchi Francesco
Objective: AGEs, compounds formed by the transformation of proteins, are increased in conditions of oxidative stress and promote inflammation by interacting with their receptor (RAGE) on cell membrane. By contrast, the soluble receptor for AGE (sRAGE), that is proteolytically cleaved from cell surface receptor via matrix metalloproteinases, sequester RAGE ligands and act as a cytoprotective and anti-inflammatory agent. AGEs/sRAGE interaction play a role in the pathogenesis of ...